A Conserved Role for Atlastin GTPases in Regulating Lipid Droplet Size
نویسندگان
چکیده
منابع مشابه
Atlastin GTPases are required for Golgi apparatus and ER morphogenesis.
The hereditary spastic paraplegias (SPG1-33) comprise a cluster of inherited neurological disorders characterized principally by lower extremity spasticity and weakness due to a length-dependent, retrograde axonopathy of corticospinal motor neurons. Mutations in the gene encoding the large oligomeric GTPase atlastin-1 are responsible for SPG3A, a common autosomal dominant hereditary spastic par...
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PURPOSE Intramyocellular lipid (IMCL) droplets are dynamic organelles whose morphology reflects their vital roles in lipid synthesis, usage, and storage in muscle energy metabolism. To develop noninvasive means to measure droplet microstructure in vivo, we investigated the molecular diffusion behavior of IMCL with diffusion magnetic resonance spectroscopy. METHODS Using extremely large diffus...
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*Present address: Genentech Inc, 1 DNA way, South San Francisco, CA 94080, USA Present address: Stony Brook School of Dental Medicine 2013, Stony Brook, NY 11790, USA Present address: Warren Alpert Medical School, Division of Biology and Medicine, Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, 171 Meeting St, Box 389, Providence, RI 02912, USA Author for c...
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Defining the mechanisms that control cell growth and division is crucial to understanding cell homeostasis, which impacts human diseases such as cancer and diabetes. IQGAP1, a widely conserved effector and/or regulator of the GTPase CDC42, is a putative oncoprotein that controls cell proliferation; however, its mechanism in tumorigenesis is unknown. The mechanistic target of rapamycin (mTOR) pa...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2013
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2013.04.015